Results In pretectal area of diabetic rat, the expression of BDNF and NGF began to decrease from 1-week DM, the expression of GFAP began to increase from 2-week DM. 结果与NC组比较,糖尿病1周大鼠顶盖前区BDNF、NGF表达减少;
Neurodegeneration and neurotrophin decrease in pretectal area, which is the target tissue of retina, might be one of the reasons resulting in retinal neurodegeneration at the early stage of diabetes. 结论糖尿病早期视网膜靶组织顶盖前区神经细胞即已出现损害,神经营养因子表达减少,糖尿病早期视网膜靶组织顶盖前区神经退行性病变可能是糖尿病早期视网膜神经元变性的原因之一。